Second year B.Pharm Sem-III (Organic chemistry-I)Theory Notes

7 Influence of the physicochemical properties of the above mentioned functional groups on the following aspects: receptor binding, formulation and degradation. Influence of the physicochemical properties on receptor binding Influence of the physicochemical properties on formulation  Influence of the physicochemical properties on degradation

5 Mechanism of SN1, SN2, E1 and E2 reactions. Factors affecting substitution and elimination reactions. Comparison of substitution and elimination reactions. Mechanism of SN1, SN2, E1 and E2 reactions. Comparison of SN1, SN2, E1 and E2 reactions Factors affecting substitution and elimination reactions.

4 Equilibria, rates and mechanisms.

3 Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Electrophiles and nucleophiles (including charged and neutral species). Concept of leaving groups, alkyl shifts and migratory aptitude. Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Electrophiles and nucleophiles (including charged and neutral species). Concept of leaving groups, alkyl shifts and migratory aptitude.

2 Ionization, acidity, basicity and pKa Ionization, acidity, basicity and pKa

Concept of configuration and chirality, axes of symmetry, plane of symmetry, center of symmetry. Representation of molecules using projection formulae - Fischer, Wedge, Sawhorse and Newmann. Geometric Isomerism: Methods of determination of configuration of geometric isomers. Optical isomerism: Enantiomers and diastereomers. Nomenclature of stereoisomers including E and Z, D and L and R and S designations. Conformations of ethane, butane, cyclohexane with their energy profile diagrams. Conformational analysis of mono- and di-substituted cyclohexanes. Types of strains: Angle strain (Baeyer Strain), transannular strain (Prelog Strain), torsional strain (Pitzer strain). Concept of configuration and chirality, axes of symmetry, plane of symmetry, center of symmetry. Representation of molecules using projection formulae - Fischer, Wedge, Sawhorse and Newmann video How to Convert Newman Projection to Fischer Projection video Geometric Isomerism: Methods of determination of con...