Second year B.Pharm Sem-III (Organic chemistry-I)Theory Notes

Answer key Answer key ANSWER KEY_OC-I_2017_QP 27660 CBCS.docx QP38126-Ans-Key-4-5-2018-2 SY_OC_semIII_key_Dec2019_65201_CBCS

7 Influence of the physicochemical properties of the above mentioned functional groups on the following aspects: receptor binding, formulation and degradation. Influence of the physicochemical properties on receptor binding Influence of the physicochemical properties on formulation  Influence of the physicochemical properties on degradation

5 Mechanism of SN1, SN2, E1 and E2 reactions. Factors affecting substitution and elimination reactions. Comparison of substitution and elimination reactions. Mechanism of SN1, SN2, E1 and E2 reactions. Comparison of SN1, SN2, E1 and E2 reactions Factors affecting substitution and elimination reactions.

4 Equilibria, rates and mechanisms.

3 Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Electrophiles and nucleophiles (including charged and neutral species). Concept of leaving groups, alkyl shifts and migratory aptitude. Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Geometry, stability and properties of the following reactive intermediates: carbocations, carbanions, carbenes and carbon radicals. Electrophiles and nucleophiles (including charged and neutral species). Concept of leaving groups, alkyl shifts and migratory aptitude.

2 Ionization, acidity, basicity and pKa Ionization, acidity, basicity and pKa

Concept of configuration and chirality, axes of symmetry, plane of symmetry, center of symmetry. Representation of molecules using projection formulae - Fischer, Wedge, Sawhorse and Newmann. Geometric Isomerism: Methods of determination of configuration of geometric isomers. Optical isomerism: Enantiomers and diastereomers. Nomenclature of stereoisomers including E and Z, D and L and R and S designations. Conformations of ethane, butane, cyclohexane with their energy profile diagrams. Conformational analysis of mono- and di-substituted cyclohexanes. Types of strains: Angle strain (Baeyer Strain), transannular strain (Prelog Strain), torsional strain (Pitzer strain). Concept of configuration and chirality, axes of symmetry, plane of symmetry, center of symmetry. Representation of molecules using projection formulae - Fischer, Wedge, Sawhorse and Newmann video How to Convert Newman Projection to Fischer Projection video Geometric Isomerism: Methods of determination of con...

1.6 Resonance in aliphatic and aromatic systems: Rules of resonance and stability of the resonance structures. Tautomerism of keto-enol and imine-enamine systems. Hyperconjugation. How to Draw Resonance Structures? video Rules for Resonance Forms Tautomerism of keto-enol video Tautomerism of imine-enamine systems video Hyperconjugation Hyperconjugation Video

Concept of aromaticity: Huckel’s rule, identification of aromatic, non-aromatic and anti-aromatic systems based on planarity, conjugation and Huckel’s rule. Concept of aromaticity Aromaticity and antiaromaticity in organic chemistryVideo

Basic concepts of electronegativity, hydrogen bonding, inductive effect, dipole moment, log P with examples of monofunctional compounds Basic concepts of electronegativity Basic concepts of hydrogen bonding Basic concept of Inductive effect Basic concept of Dipole moment Log P explained video Lg P ppt

1.3 Atomic orbitals, Molecular orbitals of sp3 (ethane), sp2 (ethene), and sp (acetylene) and C attached to heteroatoms with lone pairs. HOMO and LUMO of ethene and the C=O group Topic 1.3 Hybrid Orbitals explained - Valence Bond Theory Video HOMO and LUMO of ethene and the C=O group

1.2 Hybridization states of C, O and N. Hybridization states of C, O and N Hybridization states of C, O and N detail study Hybridization Theory video Hybridization in organic compounds video The Shape of Molecules

1.1 Nomenclature of mono/polyfunctional compounds (trivial and IUPAC) Topic 1.1 IUPAC nomenclature Handouts Topic 1.1 IUPAC nomenclature rules Topic 1.1 IUPAC nomenclature General Guidelines IUPAC names can be generated for drawn structures in the sketcher try this